Metformin and jolie

When I first discovered the anti-aging impact of Metformin - I was sold.  But being a perpetual academic, I had to dive into the research to see if food could do the same. Yes, is the answer when food is used with intention.

My prescription for myself to incur the same benefits of Metformin with food is:
Jolie Nutrition 80% of the time
Once every 2-3 months do a Deep Reset or 10 Day Reset
Maintain a solid 12+ fasting window between dinner and breakfast

Working with Dr. Amina of Simply Well has given the opportunity to begin case studies on the interaction of food and allopathic medicine.  One of the most consistent results has been that jolie gives the benefits of Metformin for non-diabetic clients.

The JolieLife diet works similarly to metformin in promoting anti-aging benefits through natural means like reducing inflammation, improving insulin sensitivity, activating AMPK, and enhancing gut health. By emphasizing whole foods, antioxidant-rich ingredients, and intermittent fasting, the diet mirrors many of metformin’s mechanisms that target aging, making it an effective lifestyle approach to healthy aging and longevity.

The fantastic bonus of food is that you not only get the effect of anti-aging, pro-metabolic medications such as Metformin, but you get the synergistic impact of food which addresses brain health, immune health, and overall wellness at the same time. 

I wanted to highlight the anti-aging pathways that jolie Nutrition targets to give you the impact of Metformin.  
1. Support for Cellular Repair

• Both metformin and Jolie nutrition support accelerated cellular repair, an essential process for anti-aging. By supporting processes like autophagy and reducing metabolic waste, jolie reduces toxic load while providing nutrients for repair.  Omega-3 fatty acids, polyphenols (found in dark berries and green tea), and amino acids from plant-based proteins and bone broths support cell repair and regeneration, helping the body recover from daily stress and maintain youthfulness.

2. Activation of AMPK (AMP-Activated Protein Kinase)

• AMPK, is a metabolic pathway that promotes cellular health and longevity by reducing inflammation and oxidative stress. Certain foods and eating patterns can naturally activate AMPK, mimicking metformin's action.
• How JolieLife Does This: The Jolie diet promotes times of non-eating and fasting with food (as part of programs like the 10 Day Reset and Deep Reset) which triggers AMPK pathways.  In addition, foods are intentionally chosen to trigger AMPK activation enhancing longevity and reducing aging markers.

3. Inhibition of mTOR Pathway

• The mTOR (mechanistic target of rapamycin) pathway is associated with aging, as its overactivation can promote cell growth but also aging-related diseases like cancer. Metformin helps suppress mTOR, slowing aging-related processes. Jolie does this by featuring plant-based proteins which naturally suppress mTOR activity.  Programs such as the 10 Day Reset and Deep Reset inhibit the mTOR pathway through mimicking fasting. This leads to improved cellular repair mechanisms and slower aging similar to metformin’s effects.

4. Anti-Inflammatory Foods

• Chronic inflammation is a key driver of aging, often referred to as inflammaging. Like metformin, which reduces pro-inflammatory cytokines, the Jolie diet emphasizes foods that naturally reduce inflammation.
• How JolieLife Does This: The diet is rich in anti-inflammatory foods like leafy greens, turmeric, ginger, berries, fatty fish (omega-3s), and other plant-based options. These foods reduce inflammation and oxidative stress, key factors in slowing down aging.

5. Improvement of Gut Health

• Both metformin and the Jolie improve gut health for a balanced microbiome which is essential for managing systemic inflammation and promoting healthy aging. Jolie focuses on gut-healing ingredients like bone broth (from the Health & Wellness Broth in some programs), fermented foods, and fiber-rich vegetables. These elements help maintain a healthy gut barrier, reduce systemic inflammation, and support a balanced microbiome, which is crucial for anti-aging.

6. Reduction of Oxidative Stress

• Metformin helps reduce oxidative stress by decreasing the production of harmful free radicals. Antioxidants, which are naturally abundant in the Jolie diet, achieve similar benefits by neutralizing free radicals, which accelerate aging. Foods like dark leafy greens, berries, nuts, seeds, and cacao provide natural defense against oxidative damage promoting long-term health.

7. Balanced Blood Sugar Levels

• Metformin’s role in reducing blood sugar spikes and improving insulin sensitivity directly impacts longevity by preventing the damage caused by advanced glycation end-products (AGEs), which are linked to aging and inflammation. Jolie modulates blood sugar by combining foods to slow glucose absorption and using foods high in insoluble fiber.  By stabilizing blood sugar levels and improving insulin sensitivity, the diet helps prevent glycation, a process where sugar molecules damage proteins and accelerate aging.

Jolie improve longevity by giving you everything you need for a long life and a life with all your systems functioning optimally.  Every program considers the nutrient needs of your entire body.  By providing you with an abundance of  vitamins, minerals, and antioxidants can achieve optimal cellular function.  

Love,
Julia
​xo